The US president has been sidelined for more than a week after he was diagnosed with Covid-19 during a critical period before the November 3 election.
The president has yet to be certified as virus-free by his medical team, but he has been cleared to resume public engagements as of this weekend.
He is expected to speak about “law and order” from a balcony to a crowd of hundreds on the lawn below.
On Monday, Mr Trump is planning to attend a campaign rally in central Florida, a must-win state for his hopes of a second term.
However questions remain over whether he is still contagious after he announced on October 2 he had the virus and spent three nights in a military hospital.
In an appearance on Fox News on Friday evening, he said he was tested again for the virus but did not disclose the result. He also said he had stopped taking medications to combat Covid-19. “I feel really strong,” he said.
Mr Trump and his administration have faced criticism for their handling of the pandemic, as well as for a lax approach to mask-wearing and social distancing in the White House and, in recent days, confusing messages about how ill the president has been.
A source familiar with the planning for the White House event said attendees were all expected to wear masks. People at the Florida rally will be given a temperature check, masks that they will be encouraged to wear and access to hand sanitiser, the campaign said.
Opinion polls show Democratic nominee Joe Biden leading Mr Trump by a significant margin in national polls, but more narrowly in some battleground states that may determine the outcome of the election.
Mr Biden criticised Mr Trump’s decision to resume campaigning. “Good luck. I wouldn’t show up unless you have a mask and can distance,” he told reporters in Paradise, Nevada.
Mr Biden will travel on Saturday to the city of Erie in northwestern Pennsylvania, a state that Mr Trump narrowly took over Hillary Clinton in the 2016 election.
Former president Barack Obama won there in the two elections before that and Mr Biden has made the region a top priority.
A Reuters/Ipsos opinion poll released earlier this week showed Biden with a five-point edge over Trump in Pennsylvania. The poll also had Mr Biden with a 10-point lead nationwide.
Mr Trump and Mr Biden will campaign next week without having to prepare for a debate.
The Commission on Presidential Debates scratched the contest set for October 15 after Mr Trump refused to take part.
The commission had shifted the face-to-face debate to a virtual one after his illness. The final debate, set for October 22, is set to go ahead as planned.
Additional reporting by Reuters